Pigmented Neurofibroma : A Case Report with Immunohistochemical and Ultrastructural Study
نویسندگان
چکیده
Pigmented neurofibroma is a rare variant of neurofibroma showing melanin production. The clinical diagnosis is difficult to establish requiring the histopathological examination to differentiate between the melanotic neurofibroma and other pigmented tumours. We report an unusual case of a huge, recurrent, pigmented neurofibroma with extended, macroscopically striking pigmentation in a 45 year old patient without stigmata of neurofibromatosis 1. The histochemical, immunohistochemical and ultrastructural findings support a melanotic line of differentiation besides Schwann cell differentiation.
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